电邮这篇文章 Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection
- 作者: Kleshchenko Y.1, Zhigunova A.1, Dalin M.1, Melnikov V.2
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隶属关系:
- Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
- Laboratory of Molecular Biology, School of Medicine, University of Colima
- 期: 卷 163, 编号 3 (2017)
- 页面: 361-364
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238895
- DOI: https://doi.org/10.1007/s10517-017-3804-0
- ID: 238895
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详细
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
作者简介
Yu. Kleshchenko
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
编辑信件的主要联系方式.
Email: ykleschenko@gmail.com
俄罗斯联邦, Moscow
A. Zhigunova
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
俄罗斯联邦, Moscow
M. Dalin
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
俄罗斯联邦, Moscow
V. Melnikov
Laboratory of Molecular Biology, School of Medicine, University of Colima
Email: ykleschenko@gmail.com
墨西哥, Colima
