Email this article Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection
- Authors: Kleshchenko Y.E.1, Zhigunova A.V.1, Dalin M.V.1, Melnikov V.2
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Affiliations:
- Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
- Laboratory of Molecular Biology, School of Medicine, University of Colima
- Issue: Vol 163, No 3 (2017)
- Pages: 361-364
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238895
- DOI: https://doi.org/10.1007/s10517-017-3804-0
- ID: 238895
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Abstract
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
About the authors
Yu. E. Kleshchenko
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Author for correspondence.
Email: ykleschenko@gmail.com
Russian Federation, Moscow
A. V. Zhigunova
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
Russian Federation, Moscow
M. V. Dalin
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
Russian Federation, Moscow
V. Melnikov
Laboratory of Molecular Biology, School of Medicine, University of Colima
Email: ykleschenko@gmail.com
Mexico, Colima
