Мақаланы E-mail арқылы жіберу Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection
- Авторлар: Kleshchenko Y.1, Zhigunova A.1, Dalin M.1, Melnikov V.2
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Мекемелер:
- Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
- Laboratory of Molecular Biology, School of Medicine, University of Colima
- Шығарылым: Том 163, № 3 (2017)
- Беттер: 361-364
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238895
- DOI: https://doi.org/10.1007/s10517-017-3804-0
- ID: 238895
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Аннотация
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
Авторлар туралы
Yu. Kleshchenko
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Хат алмасуға жауапты Автор.
Email: ykleschenko@gmail.com
Ресей, Moscow
A. Zhigunova
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
Ресей, Moscow
M. Dalin
Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia
Email: ykleschenko@gmail.com
Ресей, Moscow
V. Melnikov
Laboratory of Molecular Biology, School of Medicine, University of Colima
Email: ykleschenko@gmail.com
Мексика, Colima
