Expression of Type I Cannabinoid Receptors at Different Stages of Neuronal Differentiation of Human Fibroblasts
- 作者: Bobrov M.1,2,3, Bezuglov V.2, Khaspekov L.1, Illarioshkin S.1, Novosadova E.4, Grivennikov I.4
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隶属关系:
- Research Center of Neurology
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences
- 期: 卷 163, 编号 2 (2017)
- 页面: 272-275
- 栏目: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/238812
- DOI: https://doi.org/10.1007/s10517-017-3782-2
- ID: 238812
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详细
Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by marked stimulation of CR1 expression. In neuronal precursors, the receptors were located mainly on cell bodies and at the base of their processes. This distribution was retained at the terminal stage of differentiation of induced pluripotent stem cells into neurons.
作者简介
M. Bobrov
Research Center of Neurology; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: mbobr@mail.ru
俄罗斯联邦, Moscow; Moscow; Moscow
V. Bezuglov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
L. Khaspekov
Research Center of Neurology
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
S. Illarioshkin
Research Center of Neurology
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
E. Novosadova
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow
I. Grivennikov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
俄罗斯联邦, Moscow