Email this article Expression of Type I Cannabinoid Receptors at Different Stages of Neuronal Differentiation of Human Fibroblasts
- Authors: Bobrov M.Y.1,2,3, Bezuglov V.V.2, Khaspekov L.G.1, Illarioshkin S.N.1, Novosadova E.V.4, Grivennikov I.A.4
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Affiliations:
- Research Center of Neurology
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 163, No 2 (2017)
- Pages: 272-275
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/238812
- DOI: https://doi.org/10.1007/s10517-017-3782-2
- ID: 238812
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Abstract
Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by marked stimulation of CR1 expression. In neuronal precursors, the receptors were located mainly on cell bodies and at the base of their processes. This distribution was retained at the terminal stage of differentiation of induced pluripotent stem cells into neurons.
About the authors
M. Yu. Bobrov
Research Center of Neurology; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mbobr@mail.ru
Russian Federation, Moscow; Moscow; Moscow
V. V. Bezuglov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow
L. G. Khaspekov
Research Center of Neurology
Email: mbobr@mail.ru
Russian Federation, Moscow
S. N. Illarioshkin
Research Center of Neurology
Email: mbobr@mail.ru
Russian Federation, Moscow
E. V. Novosadova
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow
I. A. Grivennikov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
Russian Federation, Moscow
