Мақаланы E-mail арқылы жіберу Expression of Type I Cannabinoid Receptors at Different Stages of Neuronal Differentiation of Human Fibroblasts
- Авторлар: Bobrov M.1,2,3, Bezuglov V.2, Khaspekov L.1, Illarioshkin S.1, Novosadova E.4, Grivennikov I.4
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Мекемелер:
- Research Center of Neurology
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences
- Шығарылым: Том 163, № 2 (2017)
- Беттер: 272-275
- Бөлім: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/238812
- DOI: https://doi.org/10.1007/s10517-017-3782-2
- ID: 238812
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced pluripotent stem cells was accompanied by marked stimulation of CR1 expression. In neuronal precursors, the receptors were located mainly on cell bodies and at the base of their processes. This distribution was retained at the terminal stage of differentiation of induced pluripotent stem cells into neurons.
Авторлар туралы
M. Bobrov
Research Center of Neurology; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: mbobr@mail.ru
Ресей, Moscow; Moscow; Moscow
V. Bezuglov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences
Email: mbobr@mail.ru
Ресей, Moscow
L. Khaspekov
Research Center of Neurology
Email: mbobr@mail.ru
Ресей, Moscow
S. Illarioshkin
Research Center of Neurology
Email: mbobr@mail.ru
Ресей, Moscow
E. Novosadova
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
Ресей, Moscow
I. Grivennikov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: mbobr@mail.ru
Ресей, Moscow
