Assessment of Oxidative Status of the Brain and Blood Plasma in Rats with Modeled Focal Cerebral Ischemia/Reperfusion Injury
- 作者: Devyatov A.1,2, Fedorova T.2, Stvolinskii S.2, Belousova M.3, Medvedev O.3, Tutelyan V.1
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隶属关系:
- Federal Research Center of Nutrition and Biotechnology
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- 期: 卷 163, 编号 2 (2017)
- 页面: 195-198
- 栏目: Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238745
- DOI: https://doi.org/10.1007/s10517-017-3764-4
- ID: 238745
如何引用文章
详细
Parameters of the oxidative status of the brain and blood plasma were measured in rats 24 h after 1-h focal cerebral ischemia. In the brain of rats exposed to cerebral ischemia, activities of superoxide dismutase and catalase were elevated. Ischemia reduced the total antioxidant activity of the brain and the levels of malonic dialdehyde and protein carbonyl derivatives. In the blood plasma of experimental rats, superoxide dismutase activity and malonic dialdehyde level increased and total antioxidant activity decreased, i.e. the shifts were similar to those in the brain. The ischemia-induced changes in the brain and blood were not always co-directed.
作者简介
A. Devyatov
Federal Research Center of Nutrition and Biotechnology; Research Center of Neurology
编辑信件的主要联系方式.
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow; Moscow
T. Fedorova
Research Center of Neurology
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow
S. Stvolinskii
Research Center of Neurology
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow
M. Belousova
M. V. Lomonosov Moscow State University
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow
O. Medvedev
M. V. Lomonosov Moscow State University
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow
V. Tutelyan
Federal Research Center of Nutrition and Biotechnology
Email: sasha.92.jan@mail.ru
俄罗斯联邦, Moscow