Assessment of Oxidative Status of the Brain and Blood Plasma in Rats with Modeled Focal Cerebral Ischemia/Reperfusion Injury
- Authors: Devyatov A.A.1,2, Fedorova T.N.2, Stvolinskii S.L.2, Belousova M.A.3, Medvedev O.S.3, Tutelyan V.A.1
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Affiliations:
- Federal Research Center of Nutrition and Biotechnology
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- Issue: Vol 163, No 2 (2017)
- Pages: 195-198
- Section: Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238745
- DOI: https://doi.org/10.1007/s10517-017-3764-4
- ID: 238745
Cite item
Abstract
Parameters of the oxidative status of the brain and blood plasma were measured in rats 24 h after 1-h focal cerebral ischemia. In the brain of rats exposed to cerebral ischemia, activities of superoxide dismutase and catalase were elevated. Ischemia reduced the total antioxidant activity of the brain and the levels of malonic dialdehyde and protein carbonyl derivatives. In the blood plasma of experimental rats, superoxide dismutase activity and malonic dialdehyde level increased and total antioxidant activity decreased, i.e. the shifts were similar to those in the brain. The ischemia-induced changes in the brain and blood were not always co-directed.
About the authors
A. A. Devyatov
Federal Research Center of Nutrition and Biotechnology; Research Center of Neurology
Author for correspondence.
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow; Moscow
T. N. Fedorova
Research Center of Neurology
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow
S. L. Stvolinskii
Research Center of Neurology
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow
M. A. Belousova
M. V. Lomonosov Moscow State University
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow
O. S. Medvedev
M. V. Lomonosov Moscow State University
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow
V. A. Tutelyan
Federal Research Center of Nutrition and Biotechnology
Email: sasha.92.jan@mail.ru
Russian Federation, Moscow