Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin—Thromboxane A2 Balance
- 作者: Kucheryavenko A.1, Spasov A.1, Tian M.1, Suzdalev K.2
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隶属关系:
- Department of Pharmacology, Volgograd State Medical University
- Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
- 期: 卷 162, 编号 6 (2017)
- 页面: 758-761
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238533
- DOI: https://doi.org/10.1007/s10517-017-3706-1
- ID: 238533
如何引用文章
详细
We investigated the effect of a new indole derivative Sbt-828 with antiaggregant properties on prostacyclin-generating activity of the vascular wall and thromboxane A2 level in platelets of intact rats. The substance under study did not affect prostacyclin production by the vascular wall and significantly reduced thromboxane A2 level, being superior to the reference drug acetylsalicylic acid by 1.6 times, as seen from reduced malonic dialdehyde level in the thrombin-induced rat platelets.
作者简介
A. Kucheryavenko
Department of Pharmacology, Volgograd State Medical University
编辑信件的主要联系方式.
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
A. Spasov
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
M. Tian
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
K. Suzdalev
Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Rostov-on-Don