Отправить статью по E-mail Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin—Thromboxane A2 Balance
- Авторы: Kucheryavenko A.1, Spasov A.1, Tian M.1, Suzdalev K.2
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Учреждения:
- Department of Pharmacology, Volgograd State Medical University
- Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
- Выпуск: Том 162, № 6 (2017)
- Страницы: 758-761
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238533
- DOI: https://doi.org/10.1007/s10517-017-3706-1
- ID: 238533
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Аннотация
We investigated the effect of a new indole derivative Sbt-828 with antiaggregant properties on prostacyclin-generating activity of the vascular wall and thromboxane A2 level in platelets of intact rats. The substance under study did not affect prostacyclin production by the vascular wall and significantly reduced thromboxane A2 level, being superior to the reference drug acetylsalicylic acid by 1.6 times, as seen from reduced malonic dialdehyde level in the thrombin-induced rat platelets.
Об авторах
A. Kucheryavenko
Department of Pharmacology, Volgograd State Medical University
Автор, ответственный за переписку.
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
A. Spasov
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
M. Tian
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
K. Suzdalev
Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
Email: aidakucheryavenko@yandex.ru
Россия, Rostov-on-Don
