Enviar artigo por via de e-mail Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin—Thromboxane A2 Balance
- Autores: Kucheryavenko A.1, Spasov A.1, Tian M.1, Suzdalev K.2
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Afiliações:
- Department of Pharmacology, Volgograd State Medical University
- Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
- Edição: Volume 162, Nº 6 (2017)
- Páginas: 758-761
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238533
- DOI: https://doi.org/10.1007/s10517-017-3706-1
- ID: 238533
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Resumo
We investigated the effect of a new indole derivative Sbt-828 with antiaggregant properties on prostacyclin-generating activity of the vascular wall and thromboxane A2 level in platelets of intact rats. The substance under study did not affect prostacyclin production by the vascular wall and significantly reduced thromboxane A2 level, being superior to the reference drug acetylsalicylic acid by 1.6 times, as seen from reduced malonic dialdehyde level in the thrombin-induced rat platelets.
Sobre autores
A. Kucheryavenko
Department of Pharmacology, Volgograd State Medical University
Autor responsável pela correspondência
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
A. Spasov
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
M. Tian
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
K. Suzdalev
Department of Chemistry of Natural and High Molecular Compounds, Faculty of Chemistry of Southern Federal University
Email: aidakucheryavenko@yandex.ru
Rússia, Rostov-on-Don
