Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging
- 作者: Ryzhak A.1, Chalisova N.1,2, Lin’kova N.1,2,3, Nichik T.2, Dudkov A.2, Kolchina N.1, Ryzhak G.1, Khalimov R.1
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隶属关系:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Peter the Great St.Petersburg Polytechnic University
- 期: 卷 162, 编号 4 (2017)
- 页面: 534-538
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238355
- DOI: https://doi.org/10.1007/s10517-017-3655-8
- ID: 238355
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详细
Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
作者简介
A.P. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg
N. Chalisova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg; St. Petersburg
N. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St.Petersburg Polytechnic University
编辑信件的主要联系方式.
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg; St. Petersburg; St. Petersburg
T. Nichik
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg
A.V. Dudkov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg
N. Kolchina
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg
G. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg
R. Khalimov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
俄罗斯联邦, St. Petersburg