Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging
- Авторы: Ryzhak A.1, Chalisova N.1,2, Lin’kova N.1,2,3, Nichik T.2, Dudkov A.2, Kolchina N.1, Ryzhak G.1, Khalimov R.1
-
Учреждения:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Peter the Great St.Petersburg Polytechnic University
- Выпуск: Том 162, № 4 (2017)
- Страницы: 534-538
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238355
- DOI: https://doi.org/10.1007/s10517-017-3655-8
- ID: 238355
Цитировать
Аннотация
Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
Об авторах
A.P. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Россия, St. Petersburg
N. Chalisova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Россия, St. Petersburg; St. Petersburg
N. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St.Petersburg Polytechnic University
Автор, ответственный за переписку.
Email: miayy@yandex.ru
Россия, St. Petersburg; St. Petersburg; St. Petersburg
T. Nichik
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Россия, St. Petersburg
A.V. Dudkov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Россия, St. Petersburg
N. Kolchina
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Россия, St. Petersburg
G. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Россия, St. Petersburg
R. Khalimov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Россия, St. Petersburg