Email this article Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging
- Authors: Ryzhak A.1, Chalisova N.I.1,2, Lin’kova N.S.1,2,3, Nichik T.E.2, Dudkov A.2, Kolchina N.V.1, Ryzhak G.A.1, Khalimov R.I.1
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Peter the Great St.Petersburg Polytechnic University
- Issue: Vol 162, No 4 (2017)
- Pages: 534-538
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238355
- DOI: https://doi.org/10.1007/s10517-017-3655-8
- ID: 238355
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Abstract
Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
About the authors
A.P. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
N. I. Chalisova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
N. S. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St.Petersburg Polytechnic University
Author for correspondence.
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
T. E. Nichik
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
A.V. Dudkov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
N. V. Kolchina
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
G. A. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
R. I. Khalimov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
