Evaluation In Vitro of Immunoregulatory Cytokines Secretion by Dendritic Cells in Mountain Skiers
- 作者: Evstratova V.1, Nikityuk D.1, Riger N.1, Fedyanina N.1, Khanferyan R.1
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隶属关系:
- Research Institute of Nutrition
- 期: 卷 162, 编号 1 (2016)
- 页面: 60-62
- 栏目: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237903
- DOI: https://doi.org/10.1007/s10517-016-3545-5
- ID: 237903
如何引用文章
详细
In vitro production of immunoregulatory cytokines (IFN-α, IL-31, TNF-β, IL-17A, IL-7, IL-1RA, IL-1α, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors. Effect of prolonged intense physical exercise on secretory activity of immune cells was investigated. In both groups, secretion of IL-1RA, IL-10, IL-1α by dendritic cells was revealed, but there were significant differences in IL-1RA, IL-1α content (p<0.05) with lower level in the group of athletes. Production of IL-17A and IL-7 by dendritic cells in the group of athletes was not detected. In athletes, several proinflammatory cytokines (IFN-α, IL-31, and TNF-β) were secreted by cells in high concentrations, in contrast to the control group. In both groups, dendritic cells did not secrete IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9.
作者简介
V. Evstratova
Research Institute of Nutrition
Email: khanferyan@ion.ru
俄罗斯联邦, Moscow
D. Nikityuk
Research Institute of Nutrition
Email: khanferyan@ion.ru
俄罗斯联邦, Moscow
N. Riger
Research Institute of Nutrition
Email: khanferyan@ion.ru
俄罗斯联邦, Moscow
N. Fedyanina
Research Institute of Nutrition
Email: khanferyan@ion.ru
俄罗斯联邦, Moscow
R. Khanferyan
Research Institute of Nutrition
编辑信件的主要联系方式.
Email: khanferyan@ion.ru
俄罗斯联邦, Moscow