Evaluation In Vitro of Immunoregulatory Cytokines Secretion by Dendritic Cells in Mountain Skiers
- Авторы: Evstratova V.1, Nikityuk D.1, Riger N.1, Fedyanina N.1, Khanferyan R.1
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Учреждения:
- Research Institute of Nutrition
- Выпуск: Том 162, № 1 (2016)
- Страницы: 60-62
- Раздел: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237903
- DOI: https://doi.org/10.1007/s10517-016-3545-5
- ID: 237903
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Аннотация
In vitro production of immunoregulatory cytokines (IFN-α, IL-31, TNF-β, IL-17A, IL-7, IL-1RA, IL-1α, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors. Effect of prolonged intense physical exercise on secretory activity of immune cells was investigated. In both groups, secretion of IL-1RA, IL-10, IL-1α by dendritic cells was revealed, but there were significant differences in IL-1RA, IL-1α content (p<0.05) with lower level in the group of athletes. Production of IL-17A and IL-7 by dendritic cells in the group of athletes was not detected. In athletes, several proinflammatory cytokines (IFN-α, IL-31, and TNF-β) were secreted by cells in high concentrations, in contrast to the control group. In both groups, dendritic cells did not secrete IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9.
Об авторах
V. Evstratova
Research Institute of Nutrition
Email: khanferyan@ion.ru
Россия, Moscow
D. Nikityuk
Research Institute of Nutrition
Email: khanferyan@ion.ru
Россия, Moscow
N. Riger
Research Institute of Nutrition
Email: khanferyan@ion.ru
Россия, Moscow
N. Fedyanina
Research Institute of Nutrition
Email: khanferyan@ion.ru
Россия, Moscow
R. Khanferyan
Research Institute of Nutrition
Автор, ответственный за переписку.
Email: khanferyan@ion.ru
Россия, Moscow
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