2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats
- 作者: Emelianov V.1, Savateeva E.1, Sidorova L.1, Tseitler T.1, Gette I.2, Bulavintseva T.2, Smirnykh S.2, Maksimova N.1, Mochulskaya N.1, Chupakhin O.1, Chereshnev V.1,2
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隶属关系:
- B. N. Yeltsin Ural Federal University
- Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
- 期: 卷 162, 编号 1 (2016)
- 页面: 35-37
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237880
- DOI: https://doi.org/10.1007/s10517-016-3538-4
- ID: 237880
如何引用文章
详细
Metabolic disorders were evaluated in rats with alloxan diabetes mellitus after administration of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine (compound L-17). Administration of L-17 reduced the severity of metabolic disorders associated with diabetes mellitus. At the end of the experiment, the concentration of glucose, glycated hemoglobin, malonic dialdehyde, and catalase activity were significantly higher and peroxidase activity was significantly lower in the group of animals receiving L-17. The decrease of glycemia, glucose concentration, and glycated hemoglobin content was reached by the 3rd-4th week of the experiment. These data suggest that correction of biochemical parameters in rats with alloxan diabetes was reached after administration of L-17 for at least 3 weeks.
作者简介
V. Emelianov
B. N. Yeltsin Ural Federal University
编辑信件的主要联系方式.
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
E. Savateeva
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
L. Sidorova
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
T. Tseitler
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
I. Gette
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
T. Bulavintseva
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
S. Smirnykh
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
N. Maksimova
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
N. Mochulskaya
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
O. Chupakhin
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg
V. Chereshnev
B. N. Yeltsin Ural Federal University; Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
俄罗斯联邦, Ekaterinburg; Ekaterinburg