2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats
- Authors: Emelianov V.V.1, Savateeva E.A.1, Sidorova L.P.1, Tseitler T.A.1, Gette I.F.2, Bulavintseva T.S.2, Smirnykh S.E.2, Maksimova N.E.1, Mochulskaya N.N.1, Chupakhin O.N.1, Chereshnev V.A.1,2
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Affiliations:
- B. N. Yeltsin Ural Federal University
- Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
- Issue: Vol 162, No 1 (2016)
- Pages: 35-37
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237880
- DOI: https://doi.org/10.1007/s10517-016-3538-4
- ID: 237880
Cite item
Abstract
Metabolic disorders were evaluated in rats with alloxan diabetes mellitus after administration of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine (compound L-17). Administration of L-17 reduced the severity of metabolic disorders associated with diabetes mellitus. At the end of the experiment, the concentration of glucose, glycated hemoglobin, malonic dialdehyde, and catalase activity were significantly higher and peroxidase activity was significantly lower in the group of animals receiving L-17. The decrease of glycemia, glucose concentration, and glycated hemoglobin content was reached by the 3rd-4th week of the experiment. These data suggest that correction of biochemical parameters in rats with alloxan diabetes was reached after administration of L-17 for at least 3 weeks.
About the authors
V. V. Emelianov
B. N. Yeltsin Ural Federal University
Author for correspondence.
Email: evvd@list.ru
Russian Federation, Ekaterinburg
E. A. Savateeva
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
L. P. Sidorova
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
T. A. Tseitler
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
I. F. Gette
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
Russian Federation, Ekaterinburg
T. S. Bulavintseva
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
Russian Federation, Ekaterinburg
S. E. Smirnykh
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
Russian Federation, Ekaterinburg
N. E. Maksimova
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
N. N. Mochulskaya
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
O. N. Chupakhin
B. N. Yeltsin Ural Federal University
Email: evvd@list.ru
Russian Federation, Ekaterinburg
V. A. Chereshnev
B. N. Yeltsin Ural Federal University; Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: evvd@list.ru
Russian Federation, Ekaterinburg; Ekaterinburg
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