CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart

A. S. Gorbunov; L. N. Maslov; S. Yu. Tsibulnikov; I. G. Khaliulin; A. V. Tsepokina; M. V. Khutornaya; A. G. Kutikhin

doi:10.1007/s10517-016-3536-6

CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart

作者: Gorbunov A.¹, Maslov L.¹, Tsibulnikov S.¹, Khaliulin I.¹, Tsepokina A.¹, Khutornaya M.¹, Kutikhin A.¹
隶属关系:
1. Research Institute for Cardiology
期: 卷 162, 编号 1 (2016)
页面: 27-29
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237872
DOI: https://doi.org/10.1007/s10517-016-3536-6
ID: 237872

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详细

CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca²⁺ overload of cardiomyocytes.