CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart

A. S. Gorbunov; L. N. Maslov; S. Yu. Tsibulnikov; I. G. Khaliulin; A. V. Tsepokina; M. V. Khutornaya; A. G. Kutikhin

doi:10.1007/s10517-016-3536-6

CB-Receptor Agonist HU-210 Mimics the Postconditioning Phenomenon of Isolated Heart

Authors: Gorbunov A.S.¹, Maslov L.N.¹, Tsibulnikov S.Y.¹, Khaliulin I.G.¹, Tsepokina A.V.¹, Khutornaya M.V.¹, Kutikhin A.G.¹
Affiliations:
1. Research Institute for Cardiology
Issue: Vol 162, No 1 (2016)
Pages: 27-29
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237872
DOI: https://doi.org/10.1007/s10517-016-3536-6
ID: 237872

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Abstract

CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca²⁺ overload of cardiomyocytes.