Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections
- 作者: Vechkapova S.1, Zapara T.1, Morozova E.2, Proskura A.1, Schul’ts E.2, Tolstikova T.2, Ratushnyak A.1
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隶属关系:
- Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- 期: 卷 161, 编号 6 (2016)
- 页面: 782-785
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237771
- DOI: https://doi.org/10.1007/s10517-016-3509-9
- ID: 237771
如何引用文章
详细
Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.
作者简介
S. Vechkapova
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
T. Zapara
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
E. Morozova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
A. Proskura
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
E. Schul’ts
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
A. Ratushnyak
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
俄罗斯联邦, Novosibirsk
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