Email this article Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections
- Authors: Vechkapova S.O.1, Zapara T.A.1, Morozova E.A.2, Proskura A.L.1, Schul’ts E.E.2, Tolstikova T.G.2, Ratushnyak A.S.1
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Affiliations:
- Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 161, No 6 (2016)
- Pages: 782-785
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237771
- DOI: https://doi.org/10.1007/s10517-016-3509-9
- ID: 237771
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Abstract
Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.
About the authors
S. O. Vechkapova
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
T. A. Zapara
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
E. A. Morozova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
A. L. Proskura
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
E. E. Schul’ts
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
T. G. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
A. S. Ratushnyak
Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences
Email: svetavech@yandex.ru
Russian Federation, Novosibirsk
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