Regulatory Effects of Urokinase on Mesenchymal Stromal Cell Migration, Proliferation, and Matrix Metalloproteinase Secretion
- 作者: Beloglazova I.1, Zubkova E.1, Tsokolaeva Z.1, Stafeev Y.1, Dergilev K.1, Ratner E.1, Shestakova M.2, Sukhareva O.2, Parfenova E.1, Men’shikov M.1
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隶属关系:
- Russian Cardiology Research and Production Complex (RCRPC)
- Endocrinology Research Centre, Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 6 (2016)
- 页面: 775-778
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237765
- DOI: https://doi.org/10.1007/s10517-016-3507-y
- ID: 237765
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详细
We studied the effect of urokinase, its recombinant forms, and domain fragments on migration and proliferation of adipose tissue mesenchymal stromal cells (MSCs) and MMP secretion by these cells. Urokinase, but not its recombinant forms, slightly induced directed migration of MSCs. Spontaneous migration of MSCs increased under the action of urokinase or its isolated kringle domain. Migration induced by platelet-derived growth factor was inhibited by proteolytically inactive form of urokinase, the kringle domain, and blocking antibody to urokinase receptor. Urokinase, its proteolytically inactive form, and kringle domain produced no effect on MSC proliferation. In contrast to platelet-derived growth factor, all urokinase forms induced secretion of MMP-9 by MSCs.
作者简介
I. Beloglazova
Russian Cardiology Research and Production Complex (RCRPC)
编辑信件的主要联系方式.
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
E. Zubkova
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
Z. Tsokolaeva
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
Yu. Stafeev
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
K. Dergilev
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
E. Ratner
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
M. Shestakova
Endocrinology Research Centre, Ministry of Health of the Russian Federation
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
O. Sukhareva
Endocrinology Research Centre, Ministry of Health of the Russian Federation
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
E. Parfenova
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow
M. Men’shikov
Russian Cardiology Research and Production Complex (RCRPC)
Email: irene.beloglazova@gmail.com
俄罗斯联邦, Moscow