Sources of Reactive Oxygen and Nitrogen Species in Tissue Microenvironment of Hernioplasty Materials
- 作者: Sarbaeva N.1, Ponomareva Y.1, Milyakova M.1, Gribkova O.1
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隶属关系:
- Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 5 (2016)
- 页面: 711-714
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237698
- DOI: https://doi.org/10.1007/s10517-016-3491-2
- ID: 237698
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详细
Titanium and polypropylene mesh endoprostheses were implanted into the rat abdominal cavity and the populations of cells migrating to their surface were analyzed. On both materials, the cells were presented mainly by macrophages that proliferated, activated, and fused to form multinuclear cells. Contact with the foreign surface triggered superoxide anion generation and myeloperoxidase synthesis by macrophages (these processes were more intense on polypropylene implants than on titanium ones) and stimulated production of nitric oxide by macrophage. It was hypothesized that the effects of free nitrogen and oxygen radicals lead to oxidation and destruction of the polypropylene endoprosthesis surface.
作者简介
N. Sarbaeva
Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation
Email: jvponomareva@mail.ru
俄罗斯联邦, Samara
Yu. Ponomareva
Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: jvponomareva@mail.ru
俄罗斯联邦, Samara
M. Milyakova
Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation
Email: jvponomareva@mail.ru
俄罗斯联邦, Samara
O. Gribkova
Institute of Experimental Medicine and Biotechnologies, Samara State Medical University, the Ministry of Health of the Russian Federation
Email: jvponomareva@mail.ru
俄罗斯联邦, Samara