Enviar artigo por via de e-mail Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing
- Autores: Machulkin A.1,2, Garanina A.2, Zhironkina O.3, Beloglazkina E.1,2, Zyk N.1, Savchenko A.2, Kotelyanskii V.1, Mazhuga A.1,2
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Afiliações:
- Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
- Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
- Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology
- Edição: Volume 161, Nº 5 (2016)
- Páginas: 706-710
- Seção: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237695
- DOI: https://doi.org/10.1007/s10517-016-3490-3
- ID: 237695
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Resumo
We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA–) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
Sobre autores
A. Machulkin
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Autor responsável pela correspondência
Email: alekseymachulkin@rambler.ru
Rússia, Moscow; Moscow
A. Garanina
Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Rússia, Moscow
O. Zhironkina
Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology
Email: alekseymachulkin@rambler.ru
Rússia, Moscow
E. Beloglazkina
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Rússia, Moscow; Moscow
N. Zyk
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: alekseymachulkin@rambler.ru
Rússia, Moscow
A. Savchenko
Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Rússia, Moscow
V. Kotelyanskii
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: alekseymachulkin@rambler.ru
Rússia, Moscow
A. Mazhuga
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Rússia, Moscow; Moscow
