Email this article Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing
- Authors: Machulkin A.E.1,2, Garanina A.S.2, Zhironkina O.A.3, Beloglazkina E.K.1,2, Zyk N.V.1, Savchenko A.G.2, Kotelyanskii V.E.1, Mazhuga A.G.1,2
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Affiliations:
- Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
- Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
- Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology
- Issue: Vol 161, No 5 (2016)
- Pages: 706-710
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237695
- DOI: https://doi.org/10.1007/s10517-016-3490-3
- ID: 237695
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Abstract
We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA–) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
About the authors
A. E. Machulkin
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Author for correspondence.
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow; Moscow
A. S. Garanina
Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow
O. A. Zhironkina
Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow
E. K. Beloglazkina
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow; Moscow
N. V. Zyk
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow
A. G. Savchenko
Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow
V. E. Kotelyanskii
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow
A. G. Mazhuga
Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS)
Email: alekseymachulkin@rambler.ru
Russian Federation, Moscow; Moscow
