Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue
- 作者: Borovskaya T.1, Dygai A.1, Shchemerova Y.1, Kamalova S.1, Mashanova V.1, Vychuzhanina A.1, Poluektova M.1, Madonov P.1, Kinsht D.1, Goldberg V.2
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隶属关系:
- E. D. Goldberg Institute of Pharmacology and Reparative Medicine
- Tomsk Research Institute of Oncology
- 期: 卷 161, 编号 5 (2016)
- 页面: 683-686
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237674
- DOI: https://doi.org/10.1007/s10517-016-3485-0
- ID: 237674
如何引用文章
详细
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
作者简介
T. Borovskaya
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
编辑信件的主要联系方式.
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
A. Dygai
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
Yu. Shchemerova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
S. Kamalova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
V. Mashanova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
A. Vychuzhanina
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
M. Poluektova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
P. Madonov
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
D. Kinsht
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
V. Goldberg
Tomsk Research Institute of Oncology
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk