Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue
- Autores: Borovskaya T.1, Dygai A.1, Shchemerova Y.1, Kamalova S.1, Mashanova V.1, Vychuzhanina A.1, Poluektova M.1, Madonov P.1, Kinsht D.1, Goldberg V.2
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Afiliações:
- E. D. Goldberg Institute of Pharmacology and Reparative Medicine
- Tomsk Research Institute of Oncology
- Edição: Volume 161, Nº 5 (2016)
- Páginas: 683-686
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237674
- DOI: https://doi.org/10.1007/s10517-016-3485-0
- ID: 237674
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Resumo
Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
Sobre autores
T. Borovskaya
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Autor responsável pela correspondência
Email: repropharm@yandex.ru
Rússia, Tomsk
A. Dygai
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
Yu. Shchemerova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
S. Kamalova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
V. Mashanova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
A. Vychuzhanina
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
M. Poluektova
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
P. Madonov
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
D. Kinsht
E. D. Goldberg Institute of Pharmacology and Reparative Medicine
Email: repropharm@yandex.ru
Rússia, Tomsk
V. Goldberg
Tomsk Research Institute of Oncology
Email: repropharm@yandex.ru
Rússia, Tomsk