Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

O. V. Semenova; V. A. Petrov; T. N. Gerasimenko; A. V. Aleksandrova; O. A. Burmistrova; A. A. Khutornenko; A. I. Osipyants; A. A. Poloznikov; D. A. Sakharov

doi:10.1007/s10517-016-3430-2

Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

作者: Semenova O.¹, Petrov V.¹, Gerasimenko T.¹, Aleksandrova A.¹, Burmistrova O.¹, Khutornenko A.¹, Osipyants A.¹, Poloznikov A.¹, Sakharov D.¹
隶属关系:
1. Moscow Aircraft Construction Institute (National Research University)
期: 卷 161, 编号 3 (2016)
页面: 425-429
栏目: Methods
URL: https://journals.rcsi.science/0007-4888/article/view/237481
DOI: https://doi.org/10.1007/s10517-016-3430-2
ID: 237481

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详细

We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.