Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

O. V. Semenova; V. A. Petrov; T. N. Gerasimenko; A. V. Aleksandrova; O. A. Burmistrova; A. A. Khutornenko; A. I. Osipyants; A. A. Poloznikov; D. A. Sakharov

doi:10.1007/s10517-016-3430-2

Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

Authors: Semenova O.V.¹, Petrov V.A.¹, Gerasimenko T.N.¹, Aleksandrova A.V.¹, Burmistrova O.A.¹, Khutornenko A.A.¹, Osipyants A.I.¹, Poloznikov A.A.¹, Sakharov D.A.¹
Affiliations:
1. Moscow Aircraft Construction Institute (National Research University)
Issue: Vol 161, No 3 (2016)
Pages: 425-429
Section: Methods
URL: https://journals.rcsi.science/0007-4888/article/view/237481
DOI: https://doi.org/10.1007/s10517-016-3430-2
ID: 237481

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Abstract

We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.