Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning
- 作者: Lishmanov Y.1, Gorbunov A.1, Maslov L.1
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隶属关系:
- Research Institute of Cardiology
- 期: 卷 161, 编号 3 (2016)
- 页面: 344-346
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237405
- DOI: https://doi.org/10.1007/s10517-016-3410-6
- ID: 237405
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详细
Experiments on isolated perfused rat heart modeled 45-min global ischemia followed by 30-min reperfusion. Ischemic postconditioning was modeled by 3 cycles of reperfusion (30 sec) and ischemia (30 sec). Cardiomyocyte necrosis was assessed by the level of creatine phosphokinase in the perfusate. Postconditioning reduced the release of creatine phosphokinase from the heart by 30%. The cardioprotective effect of ischemic postconditioning was eliminated after inhibition of protein kinase C with cheleritrin or after blockade of δ-isoform of protein kinase C with rottlerin. These findings attest to participation of protein kinase C-δ in the realization of the cardioprotective effect of postconditioning.
作者简介
Yu. Lishmanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk
A. Gorbunov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk
L. Maslov
Research Institute of Cardiology
编辑信件的主要联系方式.
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk