Role of β-Adrenoceptors and L-Type Ca2+-Channels in the Mechanism of Reperfusion-Induced Heart Injury
- 作者: Lishmanov Y.1, Maslov L.1, Mukhomedzyanov A.1
-
隶属关系:
- Research Institute of Cardiology
- 期: 卷 161, 编号 1 (2016)
- 页面: 20-23
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237056
- DOI: https://doi.org/10.1007/s10517-016-3335-0
- ID: 237056
如何引用文章
详细
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca2+-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca2+-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca2+-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.
作者简介
Yu. Lishmanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk
L. Maslov
Research Institute of Cardiology
编辑信件的主要联系方式.
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk
A. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
俄罗斯联邦, Tomsk