Role of β-Adrenoceptors and L-Type Ca2+-Channels in the Mechanism of Reperfusion-Induced Heart Injury
- Autores: Lishmanov Y.1, Maslov L.1, Mukhomedzyanov A.1
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Afiliações:
- Research Institute of Cardiology
- Edição: Volume 161, Nº 1 (2016)
- Páginas: 20-23
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237056
- DOI: https://doi.org/10.1007/s10517-016-3335-0
- ID: 237056
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Resumo
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca2+-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca2+-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca2+-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.
Sobre autores
Yu. Lishmanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk
L. Maslov
Research Institute of Cardiology
Autor responsável pela correspondência
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk
A. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk