Isolated Atrial Amyloidosis in Patients with Various Types of Atrial Fibrillation
- 作者: Sukhacheva T.1, Eremeeva M.1, Ibragimova A.1, Vaskovskii V.1, Serov R.1, Revishvili A.1
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隶属关系:
- A. N. Bakulev Federal Research Center for Cardiovascular Surgery
- 期: 卷 160, 编号 6 (2016)
- 页面: 844-849
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237001
- DOI: https://doi.org/10.1007/s10517-016-3324-3
- ID: 237001
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详细
The myocardium of the right and left atrial appendages (auricles) in patients with paroxysmal, persistent, and permanent forms of atrial fibrillation was examined by histological methods and electron microscopy. Isolated atrial amyloidosis was detected in the left (50.0-56.3% patients) and in the right (45.0-55.6% patients) atrial appendages. In all cases, immunohistochemistry revealed atrial natriuretic peptide in fibrillary amyloid deposits. Ultrastructurally, amyloid masses formed clusters of myofibrils 8-10 nm in diameter. They were chaotically located in the extracellular space along the sarcolemma as well as in membrane invaginations, dilated tubules of cardiomyocyte T-tubular system, and vascular walls. Amyloidosis was predominantly observed in women; its degree positively correlated with age of patients and duration of atrial fibrillation but negatively correlated with atrial fibrosis. The study revealed positive (in permanent atrial fibrillation) and negative (in paroxysmal atrial fibrillation) correlation of amyloidosis with myofibril content in atrial cardiomyocytes.
作者简介
T. Sukhacheva
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
编辑信件的主要联系方式.
Email: tatiana@box.ru
俄罗斯联邦, Moscow
M. Eremeeva
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
俄罗斯联邦, Moscow
A. Ibragimova
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
俄罗斯联邦, Moscow
V. Vaskovskii
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
俄罗斯联邦, Moscow
R. Serov
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
俄罗斯联邦, Moscow
A. Revishvili
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
俄罗斯联邦, Moscow
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