Isolated Atrial Amyloidosis in Patients with Various Types of Atrial Fibrillation
- Авторлар: Sukhacheva T.1, Eremeeva M.1, Ibragimova A.1, Vaskovskii V.1, Serov R.1, Revishvili A.1
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Мекемелер:
- A. N. Bakulev Federal Research Center for Cardiovascular Surgery
- Шығарылым: Том 160, № 6 (2016)
- Беттер: 844-849
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237001
- DOI: https://doi.org/10.1007/s10517-016-3324-3
- ID: 237001
Дәйексөз келтіру
Аннотация
The myocardium of the right and left atrial appendages (auricles) in patients with paroxysmal, persistent, and permanent forms of atrial fibrillation was examined by histological methods and electron microscopy. Isolated atrial amyloidosis was detected in the left (50.0-56.3% patients) and in the right (45.0-55.6% patients) atrial appendages. In all cases, immunohistochemistry revealed atrial natriuretic peptide in fibrillary amyloid deposits. Ultrastructurally, amyloid masses formed clusters of myofibrils 8-10 nm in diameter. They were chaotically located in the extracellular space along the sarcolemma as well as in membrane invaginations, dilated tubules of cardiomyocyte T-tubular system, and vascular walls. Amyloidosis was predominantly observed in women; its degree positively correlated with age of patients and duration of atrial fibrillation but negatively correlated with atrial fibrosis. The study revealed positive (in permanent atrial fibrillation) and negative (in paroxysmal atrial fibrillation) correlation of amyloidosis with myofibril content in atrial cardiomyocytes.
Авторлар туралы
T. Sukhacheva
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Хат алмасуға жауапты Автор.
Email: tatiana@box.ru
Ресей, Moscow
M. Eremeeva
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
Ресей, Moscow
A. Ibragimova
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
Ресей, Moscow
V. Vaskovskii
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
Ресей, Moscow
R. Serov
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
Ресей, Moscow
A. Revishvili
A. N. Bakulev Federal Research Center for Cardiovascular Surgery
Email: tatiana@box.ru
Ресей, Moscow