Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum
- 作者: Ivanov P.1, Faktor M.1, Karpova N.1, Cheremnykh E.1, Brusov O.1
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隶属关系:
- Mental Health Research Center
- 期: 卷 160, 编号 6 (2016)
- 页面: 775-778
- 栏目: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/236938
- DOI: https://doi.org/10.1007/s10517-016-3307-4
- ID: 236938
如何引用文章
详细
Toxicity of human blood serum for ciliate Tetrahymena pyriformis is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (e.g., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with Tetrahymena cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.
作者简介
P. Ivanov
Mental Health Research Center
编辑信件的主要联系方式.
Email: ivanovpa@mail.ru
俄罗斯联邦, Moscow
M. Faktor
Mental Health Research Center
Email: ivanovpa@mail.ru
俄罗斯联邦, Moscow
N. Karpova
Mental Health Research Center
Email: ivanovpa@mail.ru
俄罗斯联邦, Moscow
E. Cheremnykh
Mental Health Research Center
Email: ivanovpa@mail.ru
俄罗斯联邦, Moscow
O. Brusov
Mental Health Research Center
Email: ivanovpa@mail.ru
俄罗斯联邦, Moscow
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