Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum
- Авторы: Ivanov P.1, Faktor M.1, Karpova N.1, Cheremnykh E.1, Brusov O.1
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Учреждения:
- Mental Health Research Center
- Выпуск: Том 160, № 6 (2016)
- Страницы: 775-778
- Раздел: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/236938
- DOI: https://doi.org/10.1007/s10517-016-3307-4
- ID: 236938
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Аннотация
Toxicity of human blood serum for ciliate Tetrahymena pyriformis is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation (e.g., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with Tetrahymena cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.
Об авторах
P. Ivanov
Mental Health Research Center
Автор, ответственный за переписку.
Email: ivanovpa@mail.ru
Россия, Moscow
M. Faktor
Mental Health Research Center
Email: ivanovpa@mail.ru
Россия, Moscow
N. Karpova
Mental Health Research Center
Email: ivanovpa@mail.ru
Россия, Moscow
E. Cheremnykh
Mental Health Research Center
Email: ivanovpa@mail.ru
Россия, Moscow
O. Brusov
Mental Health Research Center
Email: ivanovpa@mail.ru
Россия, Moscow