Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period
- 作者: Zhdanov V.1, Udut E.1, Sotnikova L.1, Burmina Y.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Zyuz’kov G.1, Chaikovskii A.1, Stavrova L.1, Fedorova E.1, Dygai A.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- 期: 卷 160, 编号 4 (2016)
- 页面: 417-420
- 栏目: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/236721
- DOI: https://doi.org/10.1007/s10517-016-3185-9
- ID: 236721
如何引用文章
详细
We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated. Administration of deferoxamine in a dose of 1 g/kg induced hypoplasia of the erythroid hemopoietic lineage. Suppression of bone marrow erythropoiesis manifested in a decrease of hemoglobin concentration and counts of reticulocytes, erythrocytes, and erythrokaryocytes. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. These data indicate that deferoxamine can be used for modeling of iron defi ciency anemia in pregnancy.
作者简介
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
编辑信件的主要联系方式.
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
L. Sotnikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
Ya. Burmina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
E. Fedorova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
俄罗斯联邦, Tomsk
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