Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period
- Авторлар: Zhdanov V.1, Udut E.1, Sotnikova L.1, Burmina Y.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Zyuz’kov G.1, Chaikovskii A.1, Stavrova L.1, Fedorova E.1, Dygai A.1
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Мекемелер:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Шығарылым: Том 160, № 4 (2016)
- Беттер: 417-420
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/236721
- DOI: https://doi.org/10.1007/s10517-016-3185-9
- ID: 236721
Дәйексөз келтіру
Аннотация
We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated. Administration of deferoxamine in a dose of 1 g/kg induced hypoplasia of the erythroid hemopoietic lineage. Suppression of bone marrow erythropoiesis manifested in a decrease of hemoglobin concentration and counts of reticulocytes, erythrocytes, and erythrokaryocytes. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. These data indicate that deferoxamine can be used for modeling of iron defi ciency anemia in pregnancy.
Авторлар туралы
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Хат алмасуға жауапты Автор.
Email: evu8@mail.ru
Ресей, Tomsk
L. Sotnikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
Ya. Burmina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
E. Fedorova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
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