Effect of Chemically Transformed Macrocyclic Polyene Antibiotics on Tumor Cells
- Авторы: Vainshtein V.1, Nikolaevich L.2, Sultanova G.3, Bagirova A.3, Pashazade T.3, Gasimova V.4, Tagi-zade T.3,5, Kasumov K.3,5
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Учреждения:
- St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation
- Institute of Physiology, National Academy of Sciences of Belarus
- Institute of Botany, Azerbaijan National Academy of Sciences
- Azerbaijan State Academy of Physical Culture and Sport, Baku State University
- Azerbaijan State Academy of Physical Culture and Sport
- Выпуск: Том 166, № 6 (2019)
- Страницы: 735-738
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241320
- DOI: https://doi.org/10.1007/s10517-019-04429-9
- ID: 241320
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Аннотация
Comparative analysis of the effects of chemically transformed polyene antibiotics pimaricin, nystatin, lucensomycin, amphotericin B, and levorin on biological objects in vivo and in vitro revealed the greatest biological activity of original amphotericin B and levorin with its derivatives. The study also examined the effects of alkyl derivatives of amphotericin B and levorin modified in certain parts of the lactone ring on the lipid and biological membranes. It is established that methylated levorin possesses larger biological activity than the original antibiotic. Examination of the effects of alkyl derivatives of levorin and amphotericin B on cell cultures C6 (rat glioma) and HeLa (human cervical carcinoma) in vitro revealed the antitumor action of methylated levorin and original amphotericin B.
Об авторах
V. Vainshtein
St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: victor.vainshtein@pharminnotech.com
Россия, St. Petersburg
L. Nikolaevich
Institute of Physiology, National Academy of Sciences of Belarus
Email: victor.vainshtein@pharminnotech.com
Белоруссия, Minsk
G. Sultanova
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku
A. Bagirova
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku
T. Pashazade
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku
V. Gasimova
Azerbaijan State Academy of Physical Culture and Sport, Baku State University
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku
T. Tagi-zade
Institute of Botany, Azerbaijan National Academy of Sciences; Azerbaijan State Academy of Physical Culture and Sport
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku; Baku
Kh. Kasumov
Institute of Botany, Azerbaijan National Academy of Sciences; Azerbaijan State Academy of Physical Culture and Sport
Email: victor.vainshtein@pharminnotech.com
Азербайджан, Baku; Baku