Effect of Chemically Transformed Macrocyclic Polyene Antibiotics on Tumor Cells
- Authors: Vainshtein V.A.1, Nikolaevich L.N.2, Sultanova G.G.3, Bagirova A.A.3, Pashazade T.D.3, Gasimova V.K.4, Tagi-zade T.P.3,5, Kasumov K.M.3,5
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Affiliations:
- St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation
- Institute of Physiology, National Academy of Sciences of Belarus
- Institute of Botany, Azerbaijan National Academy of Sciences
- Azerbaijan State Academy of Physical Culture and Sport, Baku State University
- Azerbaijan State Academy of Physical Culture and Sport
- Issue: Vol 166, No 6 (2019)
- Pages: 735-738
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241320
- DOI: https://doi.org/10.1007/s10517-019-04429-9
- ID: 241320
Cite item
Abstract
Comparative analysis of the effects of chemically transformed polyene antibiotics pimaricin, nystatin, lucensomycin, amphotericin B, and levorin on biological objects in vivo and in vitro revealed the greatest biological activity of original amphotericin B and levorin with its derivatives. The study also examined the effects of alkyl derivatives of amphotericin B and levorin modified in certain parts of the lactone ring on the lipid and biological membranes. It is established that methylated levorin possesses larger biological activity than the original antibiotic. Examination of the effects of alkyl derivatives of levorin and amphotericin B on cell cultures C6 (rat glioma) and HeLa (human cervical carcinoma) in vitro revealed the antitumor action of methylated levorin and original amphotericin B.
About the authors
V. A. Vainshtein
St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: victor.vainshtein@pharminnotech.com
Russian Federation, St. Petersburg
L. N. Nikolaevich
Institute of Physiology, National Academy of Sciences of Belarus
Email: victor.vainshtein@pharminnotech.com
Belarus, Minsk
G. G. Sultanova
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku
A. A. Bagirova
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku
T. Dzh. Pashazade
Institute of Botany, Azerbaijan National Academy of Sciences
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku
V. Kh. Gasimova
Azerbaijan State Academy of Physical Culture and Sport, Baku State University
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku
T. P. Tagi-zade
Institute of Botany, Azerbaijan National Academy of Sciences; Azerbaijan State Academy of Physical Culture and Sport
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku; Baku
Kh. M. Kasumov
Institute of Botany, Azerbaijan National Academy of Sciences; Azerbaijan State Academy of Physical Culture and Sport
Email: victor.vainshtein@pharminnotech.com
Azerbaijan, Baku; Baku