Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension
- Авторы: Kosovtseva A.1, Bairova Т.1, Rychkova L.1, Polyakov V.1, Kolesnikova L.1
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Учреждения:
- Research Center for Family Health and Human Reproduction Problems
- Выпуск: Том 166, № 4 (2019)
- Страницы: 494-496
- Раздел: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/241133
- DOI: https://doi.org/10.1007/s10517-019-04380-9
- ID: 241133
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Аннотация
We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A (-1291С>G), norepinephrine transporter NET (-1287G>A), and D2-dopamine receptor DRD2 (-141C Ins/Del) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [CC+AA] genotypes of ADRA2A -1291C>G and NET -1287G>A polymorphisms, cortisol level, anxiety, and proneness to conflict. The combination of genotypes [CC+GG+II] of polymorphisms -1291C>G ADRA2A, -1287G>A NET and -141C Ins/Del DRD is prognostically significant, with the GG genotype NET being epistatic.
Об авторах
A. Kosovtseva
Research Center for Family Health and Human Reproduction Problems
Автор, ответственный за переписку.
Email: arjuna6402@rambler.ru
Россия, Irkutsk
Т. Bairova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Россия, Irkutsk
L. Rychkova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Россия, Irkutsk
V. Polyakov
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Россия, Irkutsk
L. Kolesnikova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Россия, Irkutsk