Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension
- Authors: Kosovtseva A.S.1, Bairova Т.А.1, Rychkova L.V.1, Polyakov V.M.1, Kolesnikova L.I.1
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Affiliations:
- Research Center for Family Health and Human Reproduction Problems
- Issue: Vol 166, No 4 (2019)
- Pages: 494-496
- Section: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/241133
- DOI: https://doi.org/10.1007/s10517-019-04380-9
- ID: 241133
Cite item
Abstract
We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A (-1291С>G), norepinephrine transporter NET (-1287G>A), and D2-dopamine receptor DRD2 (-141C Ins/Del) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [CC+AA] genotypes of ADRA2A -1291C>G and NET -1287G>A polymorphisms, cortisol level, anxiety, and proneness to conflict. The combination of genotypes [CC+GG+II] of polymorphisms -1291C>G ADRA2A, -1287G>A NET and -141C Ins/Del DRD is prognostically significant, with the GG genotype NET being epistatic.
About the authors
A. S. Kosovtseva
Research Center for Family Health and Human Reproduction Problems
Author for correspondence.
Email: arjuna6402@rambler.ru
Russian Federation, Irkutsk
Т. А. Bairova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Russian Federation, Irkutsk
L. V. Rychkova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Russian Federation, Irkutsk
V. M. Polyakov
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Russian Federation, Irkutsk
L. I. Kolesnikova
Research Center for Family Health and Human Reproduction Problems
Email: arjuna6402@rambler.ru
Russian Federation, Irkutsk