Infradian Rhythms of Resistance to a Dissociative Anesthetic in Wistar Male Rats under Normal Conditions and After Surgical Removal of the Adrenal Glands and Testes
- Authors: Dzalilova D.S.1, Diatroptova M.A.1, Mkhitarov V.A.1, Diatroptov M.E.1
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Affiliations:
- Research Institute of Human Morphology
- Issue: Vol 166, No 3 (2019)
- Pages: 413-416
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241063
- DOI: https://doi.org/10.1007/s10517-019-04362-x
- ID: 241063
Cite item
Abstract
Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Therefore, hormones of the adrenal glands and testes do not play the key role in the mechanisms of formation of the 4-day infradian rhythm.
About the authors
D. Sh. Dzalilova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Russian Federation, Moscow
M. A. Diatroptova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Russian Federation, Moscow
V. A. Mkhitarov
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Russian Federation, Moscow
M. E. Diatroptov
Research Institute of Human Morphology
Author for correspondence.
Email: diatrom@inbox.ru
Russian Federation, Moscow