Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles
- Авторы: Sharafutdinova L.1, Fedorova A.1, Bashkatov S.1, Sinel’nikov K.1, Valiullin V.2
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Учреждения:
- Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
- Department of Histology, Kazan State Medical University
- Выпуск: Том 166, № 2 (2018)
- Страницы: 279-282
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240964
- DOI: https://doi.org/10.1007/s10517-018-4332-2
- ID: 240964
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Аннотация
We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.
Об авторах
L. Sharafutdinova
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Автор, ответственный за переписку.
Email: sharafla@yandex.ru
Россия, Ufa, The Republic of Bashkortostan
A. Fedorova
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
Россия, Ufa, The Republic of Bashkortostan
S. Bashkatov
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
Россия, Ufa, The Republic of Bashkortostan
K. Sinel’nikov
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
Россия, Ufa, The Republic of Bashkortostan
V. Valiullin
Department of Histology, Kazan State Medical University
Email: sharafla@yandex.ru
Россия, Kazan, The Republic of Tatarstan
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