Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles
- 作者: Sharafutdinova L.1, Fedorova A.1, Bashkatov S.1, Sinel’nikov K.1, Valiullin V.2
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隶属关系:
- Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
- Department of Histology, Kazan State Medical University
- 期: 卷 166, 编号 2 (2018)
- 页面: 279-282
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240964
- DOI: https://doi.org/10.1007/s10517-018-4332-2
- ID: 240964
如何引用文章
详细
We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.
作者简介
L. Sharafutdinova
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
编辑信件的主要联系方式.
Email: sharafla@yandex.ru
俄罗斯联邦, Ufa, The Republic of Bashkortostan
A. Fedorova
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
俄罗斯联邦, Ufa, The Republic of Bashkortostan
S. Bashkatov
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
俄罗斯联邦, Ufa, The Republic of Bashkortostan
K. Sinel’nikov
Department of Human Physiology and General Biology, Faculty of Biology, Bashkir State University
Email: sharafla@yandex.ru
俄罗斯联邦, Ufa, The Republic of Bashkortostan
V. Valiullin
Department of Histology, Kazan State Medical University
Email: sharafla@yandex.ru
俄罗斯联邦, Kazan, The Republic of Tatarstan