Assessment of Lactate Production and Proteoglycans Synthesis by the Intact and Degenerated Intervertebral Disc Cells under the Influence of Activated Macrophages: an In Vitro Study
- Авторы: Byvaltsev V.1,2,3, Kolesnikov S.4,5, Bardonova L.1,6, Belykh E.1,6, Korytov L.1, Giers M.7, Preul M.6
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Учреждения:
- Irkutsk State Medical University
- Irkutsk Research Center of Surgery and Traumatology
- Railroad Clinical Hospital at Irkutsk-Passenger Station, Russian Railways Company
- Research Center for Problems of Family Health and Human Reproduction
- M. V. Lomonosov Moscow State University
- Barrow Neurological Institute
- Oregon State University
- Выпуск: Том 166, № 1 (2018)
- Страницы: 170-173
- Раздел: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/240888
- DOI: https://doi.org/10.1007/s10517-018-4307-3
- ID: 240888
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Аннотация
The effects of proinflammatory cytokines on the secretion of glycosaminoglycans and lactate production by normal and degenerated intervertebral disk cells were studied on the model of their co-culturing with activated macrophage-like cells. It was found that proinflammatory cytokines produced a direct effect on intervertebral disk cells in a 3D culture reducing the rate of glycolysis and synthetic activity of both normal and degenerated cells of annulus fibrosus and nucleus pulposus, which is an important factor in progression of intervertebral disk degeneration.
Об авторах
V. Byvaltsev
Irkutsk State Medical University; Irkutsk Research Center of Surgery and Traumatology; Railroad Clinical Hospital at Irkutsk-Passenger Station, Russian Railways Company
Автор, ответственный за переписку.
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Irkutsk; Irkutsk
S. Kolesnikov
Research Center for Problems of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Moscow
L. Bardonova
Irkutsk State Medical University; Barrow Neurological Institute
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Phoenix, AZ
E. Belykh
Irkutsk State Medical University; Barrow Neurological Institute
Email: byval75vadim@yandex.ru
Россия, Irkutsk; Phoenix, AZ
L. Korytov
Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Россия, Irkutsk
M. Giers
Oregon State University
Email: byval75vadim@yandex.ru
США, Corvallis, OR
M. Preul
Barrow Neurological Institute
Email: byval75vadim@yandex.ru
США, Phoenix, AZ