Assessment of Lactate Production and Proteoglycans Synthesis by the Intact and Degenerated Intervertebral Disc Cells under the Influence of Activated Macrophages: an In Vitro Study
- Авторлар: Byvaltsev V.1,2,3, Kolesnikov S.4,5, Bardonova L.1,6, Belykh E.1,6, Korytov L.1, Giers M.7, Preul M.6
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Мекемелер:
- Irkutsk State Medical University
- Irkutsk Research Center of Surgery and Traumatology
- Railroad Clinical Hospital at Irkutsk-Passenger Station, Russian Railways Company
- Research Center for Problems of Family Health and Human Reproduction
- M. V. Lomonosov Moscow State University
- Barrow Neurological Institute
- Oregon State University
- Шығарылым: Том 166, № 1 (2018)
- Беттер: 170-173
- Бөлім: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/240888
- DOI: https://doi.org/10.1007/s10517-018-4307-3
- ID: 240888
Дәйексөз келтіру
Аннотация
The effects of proinflammatory cytokines on the secretion of glycosaminoglycans and lactate production by normal and degenerated intervertebral disk cells were studied on the model of their co-culturing with activated macrophage-like cells. It was found that proinflammatory cytokines produced a direct effect on intervertebral disk cells in a 3D culture reducing the rate of glycolysis and synthetic activity of both normal and degenerated cells of annulus fibrosus and nucleus pulposus, which is an important factor in progression of intervertebral disk degeneration.
Авторлар туралы
V. Byvaltsev
Irkutsk State Medical University; Irkutsk Research Center of Surgery and Traumatology; Railroad Clinical Hospital at Irkutsk-Passenger Station, Russian Railways Company
Хат алмасуға жауапты Автор.
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Irkutsk; Irkutsk
S. Kolesnikov
Research Center for Problems of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Moscow
L. Bardonova
Irkutsk State Medical University; Barrow Neurological Institute
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Phoenix, AZ
E. Belykh
Irkutsk State Medical University; Barrow Neurological Institute
Email: byval75vadim@yandex.ru
Ресей, Irkutsk; Phoenix, AZ
L. Korytov
Irkutsk State Medical University
Email: byval75vadim@yandex.ru
Ресей, Irkutsk
M. Giers
Oregon State University
Email: byval75vadim@yandex.ru
АҚШ, Corvallis, OR
M. Preul
Barrow Neurological Institute
Email: byval75vadim@yandex.ru
АҚШ, Phoenix, AZ