Melatonin—Aluminum Oxide—Polymethylsiloxane Complex on Apoptosis of Liver Cells in a Model of Obesity and Type 2 Diabetes Mellitus


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Аннотация

We studied the effects of a melatonin—aluminum oxide—polymethylsiloxane complex (complex M) on the expression of apoptosis regulators Bcl-2 and Bad in the liver of homozygous db/db BKS.Cg-Dock7m+/+Leprdb/J mice with obesity and type 2 diabetes. Complex M or placebo was administered daily through the gastric tube during weeks 8-16 of life. In mice with type 2 diabetes mellitus receiving placebo, enhanced immunohistochemical reactions for proapoptotic Bad protein and weak response for anti-apoptotic Bcl-2 protein were observed. Administration of complex M shifted the ratio of apoptosis regulators: the area of Bcl-2 expression significantly increased and against the background of reduced Bad expression area. These findings attest to antiapoptotic effect of complex M in the liver on the model of type 2 diabetes mellitus.

Об авторах

S. Michurina

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Автор, ответственный за переписку.
Email: s.michurina@ngs.ru
Россия, Novosibirsk

I. Ischenko

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

S. Arkhipov

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

V. Klimontov

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

M. Cherepanova

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

M. Korolev

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

L. Rachkovskaya

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

E. Zav’yalov

Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk

V. Konenkov

Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Science

Email: s.michurina@ngs.ru
Россия, Novosibirsk


© Springer Science+Business Media, LLC, part of Springer Nature, 2017

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