Characteristics of Depressive-Like Behavior of Prenatally Stressed Male Rats with Androgen Deficiency
- Авторы: Fedotova Y.1, Akulova V.1, Pivina S.1
-
Учреждения:
- Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Выпуск: Том 162, № 5 (2017)
- Страницы: 594-596
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238397
- DOI: https://doi.org/10.1007/s10517-017-3665-6
- ID: 238397
Цитировать
Аннотация
Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.5 mg/kg, intramuscularly, for 14 days) increased depressive behavior in prenatally stressed gonadectomized males in contrast to its antidepressant effect in nonstressed gonadectomized rats. Prenatal stress considerably exacerbated depressive behavior of male rats under conditions of androgen deficiency and abolished the antidepressant effect of exogenously administered testosterone propionate.
Об авторах
Yu. Fedotova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: julia.fedotova@mail.ru
Россия, St. Petersburg
V. Akulova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: julia.fedotova@mail.ru
Россия, St. Petersburg
S. Pivina
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: julia.fedotova@mail.ru
Россия, St. Petersburg
![](/img/style/loading.gif)